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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DENND1C
All Species:
7.27
Human Site:
T676
Identified Species:
17.78
UniProt:
Q8IV53
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IV53
NP_079174.2
801
87065
T676
D
P
K
P
S
P
L
T
E
P
L
I
L
H
L
Chimpanzee
Pan troglodytes
XP_001138488
775
86507
S668
F
I
L
K
E
E
N
S
D
K
H
L
G
A
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542137
887
96006
S761
C
S
Q
G
D
P
E
S
H
L
L
I
L
H
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8CFK6
786
86671
P681
P
S
L
S
K
L
D
P
R
P
S
Q
S
P
C
Rat
Rattus norvegicus
NP_001119761
546
59730
P441
S
S
S
S
K
L
D
P
T
P
S
Q
S
P
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517017
914
100669
P792
E
P
Q
P
E
P
E
P
Q
P
E
P
E
P
V
Chicken
Gallus gallus
XP_422194
839
93195
K722
L
E
E
K
N
S
E
K
T
F
I
T
D
K
M
Frog
Xenopus laevis
Q68F67
1010
112359
T713
I
K
L
Q
T
A
M
T
D
A
N
K
Q
Q
T
Zebra Danio
Brachydanio rerio
Q6NXD8
1311
147682
S1097
D
D
E
G
G
R
G
S
K
T
P
P
L
Q
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397549
694
78747
S590
K
S
S
E
F
T
N
S
K
Q
M
T
Q
S
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
36.7
N.A.
73.5
N.A.
70.6
45.4
N.A.
51.3
37.4
34.9
20.2
N.A.
N.A.
32.5
N.A.
N.A.
Protein Similarity:
100
52.8
N.A.
77.7
N.A.
78.2
52
N.A.
62.4
53.6
49.1
32.1
N.A.
N.A.
50.1
N.A.
N.A.
P-Site Identity:
100
0
N.A.
40
N.A.
6.6
6.6
N.A.
26.6
0
6.6
13.3
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
100
20
N.A.
53.3
N.A.
6.6
6.6
N.A.
53.3
26.6
26.6
33.3
N.A.
N.A.
26.6
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
0
10
0
0
0
10
0
% A
% Cys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
20
% C
% Asp:
20
10
0
0
10
0
20
0
20
0
0
0
10
0
10
% D
% Glu:
10
10
20
10
20
10
30
0
10
0
10
0
10
0
0
% E
% Phe:
10
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% F
% Gly:
0
0
0
20
10
0
10
0
0
0
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
10
0
10
0
0
20
0
% H
% Ile:
10
10
0
0
0
0
0
0
0
0
10
20
0
0
0
% I
% Lys:
10
10
10
20
20
0
0
10
20
10
0
10
0
10
0
% K
% Leu:
10
0
30
0
0
20
10
0
0
10
20
10
30
0
30
% L
% Met:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
10
% M
% Asn:
0
0
0
0
10
0
20
0
0
0
10
0
0
0
0
% N
% Pro:
10
20
0
20
0
30
0
30
0
40
10
20
0
30
0
% P
% Gln:
0
0
20
10
0
0
0
0
10
10
0
20
20
20
0
% Q
% Arg:
0
0
0
0
0
10
0
0
10
0
0
0
0
0
10
% R
% Ser:
10
40
20
20
10
10
0
40
0
0
20
0
20
10
0
% S
% Thr:
0
0
0
0
10
10
0
20
20
10
0
20
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _